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Article

Identification of Drivers of Aneuploidy in Breast Tumors.

Cell reports - 29 May 2018

Pfister Katherine, Pipka Justyna L, Chiang Colby, Liu Yunxian, Clark Royden A, Keller Ray, Skoglund Paul, Guertin Michael J, Hall Ira M, Stukenberg P Todd

Abstract excerpt

Although aneuploidy is found in the majority of tumors, the degree of aneuploidy varies widely. It is unclear how cancer cells become aneuploid or how highly aneuploid tumors are different from those of more normal ploidy. We developed a simple computational method that measures the degree of aneuploidy or structural rearrangements of large chromosome regions of 522 human breast tumors from The Cancer Genome...

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Source

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Identifiers

PMID: 29847804
DOI: 10.1016/j.celrep.2018.04.102
PMCID: PMC5997284

Genes

FOXM1
MYBL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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