Article
Simulation Framework for Generating Intratumor Heterogeneity Patterns in a Cancer Cell Population
2017-02-19
Abstract excerpt
As cancer cell populations evolve, they accumulate a number of somatic mutations, resulting in heterogeneous subclones in the final tumor. Understanding the mechanisms that produce intratumor heterogeneity (ITH) is important for selecting the best treatment. Although some studies have involved ITH simulations, their model settings differed substantially. Thus, only limited conditions were explored in each. Herein,...
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Identifiers and source
- Literature Corpus work
- a04f251e-8bb2-516f-bcf3-499876979c5c
- DOI
- 10.1101/109801