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Article

Modeling tumor progression in heterogeneous microenvironments: A cellular automata approach.

Journal of theoretical biology - 7 Apr 2026

Deng Yue, Li Mingjing, Lei Jinzhi

Abstract excerpt

Understanding how microenvironmental heterogeneity influences tumor progression is essential for advancing both cancer biology and therapeutic strategies. In this study, we develop a cellular automata (CA) model to simulate tumor growth under varying microenvironmental conditions and genetic mutation rates, addressing a gap in existing studies that rarely integrate these two factors to explain tumor dynamics. The...

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Identifiers

PMID: 41581855
DOI: 10.1016/j.jtbi.2026.112388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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