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Article

Tension-Time Integrals and Genetic Cardiomyopathy: The Force Is with You.

Cell - 19 May 2016

Dorn Gerald W

Abstract excerpt

Hundreds of different mutations in genes encoding a few dozen sarcomeric proteins cause two reciprocal human disease phenotypes, hypertrophic or dilated cardiomyopathy. How molecular dysfunction evokes different patterns of cardiac remodeling is unclear. Davis et al. describe a biophysical metric of cardiomyocyte function, the force-time integral, which predicts disease phenotype.

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Identifiers

PMID: 27203107
DOI: 10.1016/j.cell.2016.04.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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