Article
A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy.
Cell - 19 May 2016
Davis Jennifer, Davis L Craig, Correll Robert N, Makarewich Catherine A, Schwanekamp Jennifer A, Moussavi-Harami Farid, Wang Dan, York Allen J, Wu Haodi, Houser Steven R, Seidman Christine E, Seidman Jonathan G, Regnier Michael, Metzger Joseph M, Wu Joseph C, Molkentin Jeffery D
Abstract excerpt
The heart either hypertrophies or dilates in response to familial mutations in genes encoding sarcomeric proteins, which are responsible for contraction and pumping. These mutations typically alter calcium-dependent tension generation within the sarcomeres, but how this translates into the spectrum of hypertrophic versus dilated cardiomyopathy is unknown. By generating a series of cardiac-specific mouse models...
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