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Article

Towards causally cohesive genotype-phenotype modelling for characterization of the soft-tissue mechanics of the heart in normal and pathological geometries.

Journal of the Royal Society, Interface - 6 May 2015

Nordbø Øyvind, Gjuvsland Arne B, Nermoen Anders, Land Sander, Niederer Steven, Lamata Pablo, Lee Jack, Smith Nicolas P, Omholt Stig W, Vik Jon Olav

Abstract excerpt

A scientific understanding of individual variation is key to personalized medicine, integrating genotypic and phenotypic information via computational physiology. Genetic effects are often context-dependent, differing between genetic backgrounds or physiological states such as disease. Here, we analyse in silico genotype-phenotype maps (GP map) for a soft-tissue mechanics model of the passive inflation phase of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Elastic Modulus

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Share to Stress, Mechanical

Share to Ventricular Dysfunction, Left

Source

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Identifiers

PMID: 25833237
DOI: 10.1098/rsif.2014.1166
PMCID: PMC4424664

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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