Bottleneck, Isolate, Amplify, Select (BIAS) as a Mechanistic Framework for Intracellular Population Dynamics of Positive Sense RNA Viruses

Abstract excerpt

Many positive sense RNA viruses, especially those infecting plants, are known to experience stringent, stochastic population bottlenecks inside the cells they invade, but exactly how and why these populations become bottlenecked are unclear. A model proposed ten years ago advocates that such bottlenecks are evolutionarily favored because they cause the isolation of individual viral variants in separate cells. Such...

Topics

Open a Topic to create a Post that cites this publication.

• Cells, Cultured
• Cricetinae
• Epithelial Cells
• Genetic Variation
• Genome, Viral
• High-Throughput Nucleotide Sequencing
• Single-Cell Analysis
• Virology

Identifiers and source

Literature Corpus work

a01a24ac-8370-564d-9528-7b2097a7be72

DOI

10.20944/preprints202003.0021.v2