Article
Quantitative characterization of defective virus emergence by deep sequencing.
Journal of virology - 1 Mar 2014
Timm Collin, Akpinar Fulya, Yin John
Abstract excerpt
UNLABELLED: Populations of RNA viruses can spontaneously produce variants that differ in genome size, sequence, and biological activity. Defective variants that lack essential genes can nevertheless reproduce by coinfecting cells with viable virus, a process that interferes with virus growth. How such defective interfering particles (DIPs) change in abundance and biological activity within a virus population is...
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