Quantitative characterization of defective virus emergence by deep sequencing.

doi:10.1128/JVI.02675-13

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Article

Quantitative characterization of defective virus emergence by deep sequencing.

Journal of virology - 1 Mar 2014

Timm Collin, Akpinar Fulya, Yin John

Abstract excerpt

UNLABELLED: Populations of RNA viruses can spontaneously produce variants that differ in genome size, sequence, and biological activity. Defective variants that lack essential genes can nevertheless reproduce by coinfecting cells with viable virus, a process that interferes with virus growth. How such defective interfering particles (DIPs) change in abundance and biological activity within a virus population is...

Topics

Animals
Base Sequence
Cell Line
Cricetinae
Defective Viruses
Genetic Variation
Genome, Viral
High-Throughput Nucleotide Sequencing
Molecular Sequence Data
RNA Viruses
Sequence Deletion
Vesicular stomatitis Indiana virus
Viral Interference
Virus Replication

Source

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Identifiers

PMID: 24352442
DOI: 10.1128/JVI.02675-13
PMCID: PMC3958049

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