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Article

Pazopanib reveals a role for tumor cell B-Raf in the prevention of HER2+ breast cancer brain metastasis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2011

Gril Brunilde, Palmieri Diane, Qian Yong, Smart DeeDee, Ileva Lilia, Liewehr David J, Steinberg Seth M, Steeg Patricia S

Abstract excerpt

PURPOSE: Brain metastases of breast cancer contribute significantly to patient morbidity and mortality. We have tested pazopanib, a recently approved antiangiogenic drug that targets VEGFR1, VEGFR2, VEGFR3, PDGFRβ, PDGFRα, and c-kit, for prevention of experimental brain metastases and mechanism of action. EXPERIMENTAL DESIGN: In vitro assays included B-Raf enzymatic assays, Western blots, and angiogenesis assays....

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Identifiers

PMID: 21081656
DOI: 10.1158/1078-0432.CCR-10-1603
PMCID: PMC3059742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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