Article

Cerebellum metastasis model of HER2-positive breast cancer unveils key role of IL34-induced Arg1+ macrophages

2025-06-23

Abstract excerpt

<h4>SUMMARY</h4> Brain metastases occur in up to 40% of Stage IV breast cancer patients. The cerebellum is a frequent location for metastases in HER2-positive breast cancer patients, but the mechanisms for this are unknown. Here, we developed a syngeneic, immunocompetent mouse model for breast cancer brain metastases by stereotactically injecting mouse HER2-overexpressing breast cancer organoids into the cerebell...

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Literature Corpus work: 0d2dfb80-e553-50b9-84c3-fa9142546850
DOI: 10.1101/2025.06.17.660224

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