Article
HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer.
Breast cancer research : BCR - 1 Jan 2010
Da Silva Leonard, Simpson Peter T, Smart Chanel E, Cocciardi Sibylle, Waddell Nic, Lane Annette, Morrison Brian J, Vargas Ana Cristina, Healey Sue, Beesley Jonathan, Pakkiri Pria, Parry Suzanne, Kurniawan Nyoman, Reid Lynne, Keith Patricia, Faria Paulo, Pereira Emilio, Skalova Alena, Bilous Michael, Balleine Rosemary L, Do Hongdo, Dobrovic Alexander, Fox Stephen, Franco Marcello, Reynolds Brent, Khanna Kum Kum, Cummings Margaret, Chenevix-Trench Georgia, Lakhani Sunil R
Abstract excerpt
INTRODUCTION: Metastases to the brain from breast cancer have a high mortality, and basal-like breast cancers have a propensity for brain metastases. However, the mechanisms that allow cells to colonize the brain are unclear. METHODS: We used morphology, immunohistochemistry, gene expression and somatic mutation profiling to analyze 39 matched pairs of primary breast cancers and brain metastases, 22 unmatched...
Topics
- Blotting, Western
- Brain Neoplasms
- Breast Neoplasms
- Class I Phosphatidylinositol 3-Kinases
- ErbB Receptors
- Female
- Gene Expression Profiling