Article

Annexin A2 mediates RIG-I-like receptor responses to viral infection

2025-10-29

Abstract excerpt

RIG-I and MDA5 are critical sensors of virus infection and detect many important human pathogens including SARS-CoV-2, influenza A virus (IAV), Zika virus and West Nile virus (WNV). MDA5 is activated by binding to double-stranded RNA generated during infection and induces strong pro-inflammatory and antiviral responses mediated largely via type I interferons. Activation of MDA5 is also implicated in monogenic (e.g...

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Literature Corpus work: 9ff42180-8c03-5d36-9275-5e5071be9453
DOI: 10.1101/2025.10.28.684968

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