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Role of Annexin A2 in the Production of Infectious Hepatitis C Virus Particles

25 Mar 2010

Abstract excerpt

Hepatitis C virus (HCV) is an important human pathogen affecting 170 million chronically infected individuals. In search for cellular proteins involved in HCV replication, we have developed a purification strategy for viral replication complexes and identified annexin A2 (ANXA2) as an associated host factor. ANXA2 colocalized with viral nonstructural proteins in cells harboring genotype 1 or 2 replicons as well...

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PMID: 20335258
DOI: 10.1128/jvi.02343-09

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