Article

Impact of disruptions in antigen processing and presentation machinery on sarcoma

2024-07-12

Abstract excerpt

<title>Abstract</title> <p>Background: The antigen processing machinery (APM) plays a critical role in generating tumor-specific antigens that can be recognized and targeted by the immune system. The status of the APM in sarcomas is not well characterized. <h4>Methods:</h4> We investigated 126 patients with 8 types of bone and soft tissue sarcoma operated between 2001-2021. Tissue microarrays mapped 11 specific a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9fee6649-68c9-5d7f-b11b-0b7ebfcfe8b4
DOI: 10.21203/rs.3.rs-4546330/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impact of disruptions in antigen processing and presentation machinery on sarcomaDOI 10.21203/rs.3.rs-4546330/v1Read

Impact of disruptions in antigen processing and presentation machinery on sarcomaSemantic proximity Read

Tumour neoantigen repertoire computational predictions in malignant peripheral nerve sheath tumours define potential targets for immunotherapySemantic proximity Read

The interplay between neoantigens and immune cells in sarcomas treated with checkpoint inhibitionSemantic proximity Read

The proteomic landscape of soft tissue sarcomasSemantic proximity Read

The link between MHC class I abnormalities of tumors, oncogenes, tumor suppressor genes, and transcription factors.Semantic proximity Read

B cells are associated with survival and immunotherapy response in sarcoma.Semantic proximity Read

A New Molecular (P)Layer in Pseudomyxoma Peritonei: The Splicing Machinery is Dysregulated and Linked to Low SurvivalSemantic proximity Read

Proteomic profiling of soft tissue sarcomas with SWATH mass spectrometrySemantic proximity Read

Multi-omics analysis in inclusion body myositis identifies mir-16 responsible for HLA overexpressionSemantic proximity Read

SARC028 samples reveal an interplay between TGF-beta, interferon signaling and low HLA class I expression as contributors to Ewing sarcoma checkpoint blockade resistanceSemantic proximity Read

Calpain-dependent antigen processing generates a tumor-associated epitope recognized by osteosarcoma-infiltrating T cellsSemantic proximity Read

Clinical Implications and Molecular Features of Extracellular Matrix Networks in Soft Tissue SarcomasSemantic proximity Read