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Article

Clinical Implications and Molecular Features of Extracellular Matrix Networks in Soft Tissue Sarcomas

29 May 2024

Abstract excerpt

PURPOSE: The landscape of extracellular matrix (ECM) alterations in soft tissue sarcomas (STS) remains poorly characterized. We aimed to investigate the tumor ECM and adhesion signaling networks present in STS and their clinical implications. EXPERIMENTAL DESIGN: Proteomic and clinical data from 321 patients across 11 histological subtypes were analyzed to define ECM and integrin adhesion networks. Subgroup...

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PMID: 38810090
DOI: 10.1158/1078-0432.ccr-23-3960

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