Article

In silico analysis of Missense Variants in Human MPL Gene Associated with Essential Thrombocythemia

2019-11-04

Abstract excerpt

<h4>Introduction</h4> The proto-oncogene (MPL) gen encodes the receptor for thrombopoietin (TPO-R), a member of hematopoietic receptor superfamily. Thrombopoietin (TPO), the primary cytokine regulating self-renewal of hematopoietic stem cells, thrombopoiesis and megakaryocytopoiesis. TPO binding to TPO-R induces activation of Janus Kinase 2 (JAK2). Activated JAK2 triggers the activation of downstream positive sig...

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Literature Corpus work: 9fc73524-0675-5e78-a5cb-3b3372c14967
DOI: 10.1101/830372

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