Article

The Roles of Genetic and Epigenetic Abnormalities in Essential Thrombocythemia

2026-08-24

Abstract excerpt

Essential thrombocythemia (ET) is a Ph(-) myeloproliferative neoplasm characterized by elevated platelet counts. Patients most often have one of the three following driver mutations: JAK2, MPL, or CALR. However, these mutations are not detected in approximately 10–15% of patients, who are thus referred to as “triple-negative” (TN). Background/Objectives: In recent years, there have been breakthroughs in the geneti...

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Literature Corpus work: 22526e06-0c5b-57e0-92d2-9142d0038a71
DOI: 10.3390/genes17090989

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