Article

Structure simulation of thrombopoietin receptor C-MPL with missense SNPs and its geographical distribution

2018-06-08

Abstract excerpt

Mpl is a key gene controlling the process of proliferation and differentiation of megakaryocyte and several studies reported that the mutation of mpl will even cause accurate megakaryocyte leukemia. By overlapping the missense mutation in NCBI and recorded SNP in 1000 genome database, we sorted out 4 SNPs(rs190983971, rs563996763, rs546510242, rs373621350) to find out its conformational changes. With Phyre v2.0, w...

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Literature Corpus work: 2cedd63b-1121-56c3-a175-927273bd1f9c
DOI: 10.1101/342089

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