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Article

JAK and MPL mutations in myeloid malignancies.

Leukemia & lymphoma - 1 Mar 2008

Tefferi Ayalew

Abstract excerpt

The Janus family of non-receptor tyrosine kinases (JAK1, JAK2, JAK3 and tyrosine kinase 2) transduces signals downstream of type I and II cytokine receptors via signal transducers and activators of transcription (STATs). JAK3 is important in lymphoid and JAK2 in myeloid cell proliferation and differentiation. The thrombopoietin receptor MPL is one of several JAK2 cognate receptors and is essential for...

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Topics

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Share to JAK3 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18297515
DOI: 10.1080/10428190801895360

Genes

JAK2
MPL
JAK3
BCR
ETV6
JAK1
PCM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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