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Article

Identification of putative noncanonical driver mutations in patients with essential thrombocythemia.

European journal of haematology - 1 Jun 2023

Arai Akihiko, Yoshimitsu Makoto, Otsuka Maki, Ito Yoshikiyo, Miyazono Takayoshi, Nakano Nobuaki, Obama Kosuke, Nakashima Hidetoshi, Hanada Shuichi, Owatari Satsuki, Nakamura Daisuke, Tokunaga Masahito, Kamada Yuhei, Utsunomiya Atae, Haraguchi Koichi, Hayashida Maiko, Fujino Satoshi, Odawara Jun, Tabuchi Tomohisa, Suzuki Shinsuke, Hamada Heiichiro, Kawamoto Yoshiko, Uchida Yuichiro, Hachiman Miho, Ishitsuka Kenji

Abstract excerpt

Essential thrombocythemia (ET) cases without canonical JAK2, CALR, or MPL mutations, that is, triple-negative (TN) ET, have been found in 10%-20% of ET cases. Owing to the limited number of TN ET cases, its clinical significance remains unclear. This study evaluated TN ET's clinical characteristics and identified novel driver mutations. Among 119 patients with ET, 20 (16.8%) had no canonical JAK2/CALR/MPL...

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Identifiers

PMID: 36811253
DOI: 10.1111/ejh.13945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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