Thrombopoietin Receptor MPL in Hematopoiesis and Myeloproliferative Neoplasms: Physiological Roles and Pathogenic Mechanisms.

Abstract excerpt

MPL (myeloproliferative leukemia virus) is a type I transmembrane glycoprotein acting as the receptor for thrombopoietin (TPO). Increasing evidence indicates that MPL is essential for stem cell maintenance and megakaryopoiesis. Activating mutations in MPL have been identified as the major driver mutations of myeloproliferative neoplasms (MPNs) characterized by excessive proliferation of multiple lineages. Given...

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