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Article

Different mutations of the human c-mpl gene indicate distinct haematopoietic diseases.

Journal of hematology & oncology - 25 Jan 2013

He Xin, Chen Zhigang, Jiang Yangyan, Qiu Xi, Zhao Xiaoying

Abstract excerpt

The human c-mpl gene (MPL) plays an important role in the development of megakaryocytes and platelets as well as the self-renewal of haematopoietic stem cells. However, numerous MPL mutations have been identified in haematopoietic diseases. These mutations alter the normal regulatory mechanisms and lead to autonomous activation or signalling deficiencies. In this review, we summarise 59 different MPL mutations...

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Source

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Identifiers

PMID: 23351976
DOI: 10.1186/1756-8722-6-11
PMCID: PMC3563459

Genes

MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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