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Article

Efficient gene-environment interaction tests for large biobank-scale sequencing studies.

Genetic epidemiology - 1 Nov 2020

Wang Xinyu, Lim Elise, Liu Ching-Ti, Sung Yun Ju, Rao Dabeeru C, Morrison Alanna C, Boerwinkle Eric, Manning Alisa K, Chen Han

Abstract excerpt

Complex human diseases are affected by genetic and environmental risk factors and their interactions. Gene-environment interaction (GEI) tests for aggregate genetic variant sets have been developed in recent years. However, existing statistical methods become rate limiting for large biobank-scale sequencing studies with correlated samples. We propose efficient Mixed-model Association tests for GEne-Environment...

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Identifiers

PMID: 32864785
DOI: 10.1002/gepi.22351
PMCID: PMC7754763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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