Article
The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.
Gastroenterology - 1 May 2016
Mancina Rosellina Margherita, Dongiovanni Paola, Petta Salvatore, Pingitore Piero, Meroni Marica, Rametta Raffaela, Borén Jan, Montalcini Tiziana, Pujia Arturo, Wiklund Olov, Hindy George, Spagnuolo Rocco, Motta Benedetta Maria, Pipitone Rosaria Maria, Craxì Antonio, Fargion Silvia, Nobili Valerio, Käkelä Pirjo, Kärjä Vesa, Männistö Ville, Pihlajamäki Jussi, Reilly Dermot F, Castro-Perez Jose, Kozlitina Julia, Valenti Luca, Romeo Stefano
Abstract excerpt
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver damage and is characterized by steatosis. Genetic factors increase risk for progressive NAFLD. A genome-wide association study showed that the rs641738 C>T variant in the locus that contains the membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7, also called LPIAT1) and transmembrane channel-like 4 gene (TMC4)...
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