Article

TMEM65 regulates NCLX-dependent mitochondrial calcium efflux

2023-10-09

Abstract excerpt

The balance between mitochondrial calcium ( m Ca 2+ ) uptake and efflux regulates ATP production, but if perturbed causes energy starvation or m Ca 2+ overload and cell death. The mitochondrial sodium-calcium exchanger, NCLX, is a critical route of m Ca 2+ efflux in excitable tissues, such as the heart and brain, and animal models support NCLX as a promising therapeutic target to limit pathogenic m Ca 2+ o...

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Literature Corpus work: 9fa9da8b-b233-59e1-91be-fd1497c469e9
DOI: 10.1101/2023.10.06.561062

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