Colorectal adenocarcinomas downregulate the mitochondrial Na ⁺ /Ca ²⁺ exchanger NCLX to drive metastatic spread

Abstract excerpt

<h4>Summary</h4> Despite the established role of mitochondria in tumorigenesis, the molecular mechanisms by which mitochondrial Ca 2+ (mtCa 2+ ) signaling regulates tumor growth and metastasis remain unknown. The crucial role of mtCa 2+ in tumorigenesis is highlighted by the altered expression of proteins mediating mtCa 2+ uptake and extrusion in cancer cells. Here, we demonstrate that expression of the mitoc...

Topics

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• Cancer, Hypoxia, and Metabolism
• Glioma Diagnosis and Treatment
• Mitochondrial Function and Pathology
• Neoplasms
• Phenotype
• Sodium
• Tumor Microenvironment
• Voltage-Gated Sodium Channels

Identifiers and source

Literature Corpus work

d14279b1-a0a5-5e4f-a999-1b836744aca7

DOI

10.1101/2020.05.07.083071