Article

Data-driven brain atrophy staging in spinocerebellar ataxia type 3

2024-05-29

Abstract excerpt

Spinocerebellar ataxia type 3 (SCA3) is the most common autosomal dominant ataxia worldwide. First targeted gene therapy trials have started, offering the intriguing scenario of preventive treatment. SCA3 is associated with progressive regional brain atrophy that starts before clinical manifestation. We aimed to identify the spatiotemporal progression pattern of brain atrophy of SCA3 with a focus on early disease...

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Literature Corpus work: 9f8f5905-6f59-5934-bf76-99e49704bea1
DOI: 10.1101/2024.05.29.24307992

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