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Article

Stage‐Dependent Biomarker Changes in Spinocerebellar Ataxia Type 3

14 Nov 2023

Abstract excerpt

Spinocerebellar ataxia type 3/Machado-Joseph disease is the most common autosomal dominant ataxia. In view of the development of targeted therapies, knowledge of early biomarker changes is needed. We analyzed cross-sectional data of 292 spinocerebellar ataxia type 3/Machado-Joseph disease mutation carriers. Blood concentrations of mutant ATXN3 were high before and after ataxia onset, whereas neurofilament light...

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PMID: 37962377
DOI: 10.1002/ana.26824

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