Article

Modeling disease progression in spinocerebellar ataxias

2024-05-31

Abstract excerpt

<h4>Background and objectives</h4> The most common autosomal-dominantly inherited spinocerebellar ataxias (SCA), SCA1, SCA2, SCA3 and SCA6, account for more than half of all SCA families. Disease course is characterized by progressive ataxia and additional neurological signs. Each of these SCAs is caused by a CAG repeat expansion, leading to an expanded polyglutamine stretch in the resulting type-specific protein....

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Literature Corpus work: 7c85306e-7a11-56a0-bbcc-02aa96ad72da
DOI: 10.1101/2024.05.29.24308162

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