Article

Impaired oligodendrocyte maturation is an early feature in SCA3 disease pathogenesis

2021-11-19

Abstract excerpt

<h4>ABSTRACT</h4> Spinocerebellar ataxia type 3 (SCA3), the most common dominantly inherited ataxia, is a polyglutamine neurodegenerative disease for which there is no disease-modifying therapy. The polyglutamine-encoding CAG repeat expansion in the ATXN3 gene results in expression of a mutant form of the ATXN3 protein, a deubiquitinase that causes selective neurodegeneration despite being widely expressed. The...

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Literature Corpus work: 2b390229-158f-54f2-a18f-d499787c2a93
DOI: 10.1101/2021.11.18.468958

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