Article
Genotype-specific patterns of atrophy progression are more sensitive than clinical decline in SCA1, SCA3 and SCA6.
Brain : a journal of neurology - 1 Mar 2013
Reetz Kathrin, Costa Ana S, Mirzazade Shahram, Lehmann Anna, Juzek Agnes, Rakowicz Maria, Boguslawska Romana, Schöls Ludger, Linnemann Christoph, Mariotti Caterina, Grisoli Marina, Dürr Alexandra, van de Warrenburg Bart P, Timmann Dagmar, Pandolfo Massimo, Bauer Peter, Jacobi Heike, Hauser Till-Karsten, Klockgether Thomas, Schulz Jörg B
Abstract excerpt
Spinocerebellar ataxias are dominantly inherited disorders that are associated with progressive brain degeneration, mainly affecting the cerebellum and brainstem. As part of the multicentre European integrated project on spinocerebellar ataxias study, 37 patients with spinocerebellar ataxia-1, 19 with spinocerebellar ataxia-3 and seven with spinocerebellar ataxia-6 were clinically examined and underwent magnetic...
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