Article

Stage-dependent biomarker changes in spinocerebellar ataxia type 3

2023-04-25

Abstract excerpt

Spinocerebellar ataxia type 3/Machado–Joseph disease (SCA3) is the most common autosomal dominant ataxia. In view of the development of targeted therapies for SCA3, precise knowledge of stage-dependent fluid and MRI biomarker changes is needed. We analyzed cross-sectional data of 292 SCA3 mutation carriers including 57 pre-ataxic individuals, and 108 healthy controls from the European Spinocerebellar ataxia type 3...

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Literature Corpus work: bff0c4b1-9ada-5166-8145-610f81fae08a
DOI: 10.1101/2023.04.21.23287817

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