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Article

Penetrance of <i>HFE</i> haemochromatosis variants to clinical disease: polygenic risk score associations in UK Biobank

2022-03-09

Abstract excerpt

<h4>Background</h4> The iron overload condition Hereditary Heamochromatosis (HH) can cause liver cirrhosis and cancer, diabetes and arthritis. In Europeans, most HH disease occurs in male HFE p.C282Y homozygotes, yet only a minority of homozygotes in the general population develop these conditions. We aimed to determine whether common genetic variants influencing iron levels or risks for liver, diabetes or arthrit...

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Literature Corpus work
07616e34-3c7f-54d5-9325-8cf28e3f649a
DOI
10.1101/2022.03.08.22272084
Open publication

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Penetrance of <i>HFE</i> haemochromatosis variants to clinical disease: polygenic risk score associations in UK BiobankDOI 10.1101/2022.03.08.22272084
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