Article
Hereditary hemochromatosis: insights from the Hemochromatosis and Iron Overload Screening (HEIRS) Study.
Hematology. American Society of Hematology. Education Program - 1 Jan 2009
McLaren Gordon D, Gordeuk Victor R
Abstract excerpt
Hemochromatosis comprises a group of inherited disorders resulting from mutations of genes involved in regulating iron metabolism. The multicenter, multi-ethnic Hemochromatosis and Iron Overload Screening (HEIRS) Study screened approximately 100,000 participants in the US and Canada, testing for HFE mutations, serum ferritin and transferrin saturation. As in other studies, HFE C282Y homozygosity was common in...
Topics
- Adult
- Aged
- Aged, 80 and over
- Antimicrobial Cationic Peptides
- Canada
- Ethnicity
- Female
- Ferritins
- Genetic Heterogeneity
- Genotype
- Hemochromatosis
- Hemochromatosis Protein
- Hepcidins
- Histocompatibility Antigens Class I