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Article

Evidence of a Role for Fibroblast Transient Receptor Potential Canonical 3 Ca2+ Channel in Renal Fibrosis.

Journal of the American Society of Nephrology : JASN - 1 Aug 2015

Saliba Youakim, Karam Ralph, Smayra Viviane, Aftimos Georges, Abramowitz Joel, Birnbaumer Lutz, Farès Nassim

Abstract excerpt

Transient receptor potential canonical (TRPC) Ca(2+)-permeant channels, especially TRPC3, are increasingly implicated in cardiorenal diseases. We studied the possible role of fibroblast TRPC3 in the development of renal fibrosis. In vitro, a macromolecular complex formed by TRPC1/TRPC3/TRPC6 existed in isolated cultured rat renal fibroblasts. However, specific blockade of TRPC3 with the pharmacologic inhibitor...

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Source

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Identifiers

PMID: 25479966
DOI: 10.1681/ASN.2014010065
PMCID: PMC4520158

Genes

TRPC3
TRPC1
TRPC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence of a Role for Fibroblast Transient Receptor Potential Canonical 3 Ca2+ Channel in Renal Fibrosis.PMID 25479966Read ↗

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