TRPM7-Mediated Ca ²⁺ Signals Confer Fibrogenesis in Human Atrial Fibrillation

Abstract excerpt

RATIONALE: Cardiac fibrosis contributes to pathogenesis of atrial fibrillation (AF), which is the most commonly sustained arrhythmia and a major cause of morbidity and mortality. Although it has been suggested that Ca(2+) signals are involved in fibrosis promotion, the molecular basis of Ca(2+) signaling mechanisms and how Ca(2+) signals contribute to fibrogenesis remain unknown. OBJECTIVE: To determine the...

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