Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of RUNX1 blocks the differentiation of lung fibroblasts to myofibroblasts

19 Jan 2022

Abstract excerpt

Pathological fibrosis contributes to progression of various diseases, for which the therapeutic options are limited. Idiopathic pulmonary fibrosis (IPF) is one such progressive and fatal interstitial fibrotic disease that is often characterized by excessive accumulation of extracellular matrix (ECM) proteins leading to stiff lung tissue and impaired gas exchange. However, the molecular mechanisms underlying IPF...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Share to Occupational and environmental lung diseases
Share to Pulmonary Hypertension Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35048404
DOI: 10.1002/jcp.30684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of RUNX1 blocks the differentiation of lung fibroblasts to myofibroblastsPMID 35048404Read ↗

Runt-related transcription factors: from pathogenesis to therapeutic targets in multiple-organ fibrosisSemantic proximity Read ↗

Hypoxia and transforming growth factor β1 regulation of long non‐coding RNA transcriptomes in human pulmonary fibroblastsSemantic proximity Read ↗

Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host MediatorsSemantic proximity Read ↗

RNA-sequencing comparison of pneumonectomy and bleomycin reveals anti-fibrotic mechanisms of lung fibroblastsSemantic proximity Read ↗

Sine oculis homeobox homolog 1 plays a critical role in pulmonary fibrosisSemantic proximity Read ↗

Single-Cell RNA Sequencing Provides New Insights into Therapeutic Roles of Thyroid Hormone in Idiopathic Pulmonary FibrosisSemantic proximity Read ↗

Lung fibroblasts express a miR-19a-19b-20a sub-cluster to suppress TGF-β-associated fibroblast activation in murine pulmonary fibrosisSemantic proximity Read ↗

Myocardin-related Transcription Factor-A Complexes Activate Type I Collagen Expression in Lung FibroblastsSemantic proximity Read ↗

Molecular Interplay in Cardiac Fibrosis: Exploring the Functions of RUNX2, BMP2, and NotchSemantic proximity Read ↗

RUNX1 is Expressed in a Subpopulation of Dermal Fibroblasts and Higher RUNX1 Levels are Associated with the Severity of Systemic SclerosisSemantic proximity Read ↗

RUNX1: A Regulator of NF-κB Signaling in Pulmonary DiseasesSemantic proximity Read ↗

Prevention of Drug-Induced Lung Fibrosis via Inhibition of the MRTF/SRF Transcription PathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.