Article

TREK-1 knock-down in human atrial fibroblasts leads to a myofibroblastic phenotype: a role in phenoconversion and over-view of mechano-sensitive channel mRNA expression in cardiac diseases

2022-07-22

Abstract excerpt

Cardiac cell mechanical environment changes on a beat-by-beat basis and also in the course of various cardiac diseases. Cells sense and adapt to such mechanical cues via specialized mechano-sensors mediating adaptive signaling cascades. Here, we report TREK-1 mRNA expression and activity in human atrial fibroblasts and reveal a cross talk between TREK-1 and fibroblast phenoconversion. With the aim to reveal addit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cff85f7a-ef37-5480-adef-b0ab12d4c6ab
DOI: 10.1101/2022.07.21.492231

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TREK-1 knock-down in human atrial fibroblasts leads to a myofibroblastic phenotype: a role in phenoconversion and over-view of mechano-sensitive channel mRNA expression in cardiac diseasesDOI 10.1101/2022.07.21.492231Read

Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillationSemantic proximity Read

Cardiac fibroblasts and mechanosensation in heart development, health and diseaseSemantic proximity Read

Dissecting the Molecular Mechanisms Driving Electropathology in Atrial Fibrillation: Deployment of RNA Sequencing and Transcriptomic AnalysesSemantic proximity Read

Cell-Based Mechanosensation, Epigenetics, and Non-Coding RNAs in Progression of Cardiac FibrosisSemantic proximity Read

The Soft- and Hard-Heartedness of Cardiac Fibroblasts: Mechanotransduction Signaling Pathways in Fibrosis of the HeartSemantic proximity Read

The molecular and functional identities of atrial cardiomyocytes in health and disease.Semantic proximity Read

Altered physiological functions and ion currents in atrial fibroblasts from patients with chronic atrial fibrillationSemantic proximity Read

Fibroblast‐mediated intercellular crosstalk in the healthy and diseased heartSemantic proximity Read

Congestive heart failure effects on atrial fibroblast phenotype: differences between freshly-isolated and cultured cells.Semantic proximity Read

Patient and cell-type specific hiPSC-modeling of a truncating titin variant associated with atrial fibrillationSemantic proximity Read

Fine tuning contractility: atrial sarcomere function in health and diseaseSemantic proximity Read

Stimulation of cardiac fibroblast Piezo1 channels opposes myofibroblast differentiation and induces IL-6 secretion via Ca <sup>2+</sup> -mediated p38 MAP kinase activationSemantic proximity Read