Article

<i>BRCA</i> mutation alters the stromal landscape in normal ovaries

2025-10-03

Abstract excerpt

For BRCA mutation ( BRCA+ ) carriers, the risk of ovarian cancer can be as high as 59% compared with 1.4% for the general population. While the impact of BRCA mutations on epithelial cell transformation has been extensively studied, we hypothesize that these mutations cause structural changes that prematurely transform the ovary into a rich metastatic niche that supports the early onset of ovarian cancer. Analy...

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Identifiers and source

Literature Corpus work: 9f69dc7d-fe49-51fb-a14a-67d7f8aa5775
DOI: 10.1101/2025.10.01.679597

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