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Proteogenomic Profiling Reveals a Distinct Endogenous p16INK4a-Associated Senescence Signature in the Human Ovary

2026-02-04

Abstract excerpt

The tumor suppressor and cell cycle regulator, p16 INK4a (p16), has been extensively linked to cellular senescence, and its accumulation can reflect endogenous senescence within ovarian tissue. However, gene and protein signatures associated with p16 have not been well defined in human tissue. We utilized immunohistochemical (IHC) staining for P16 to identify distinct positive (P16+) and negative (P16-) regions w...

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Literature Corpus work
3c1e065a-5111-547c-9594-fe6d35b912aa
DOI
10.64898/2026.02.02.703302
Open publication

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Proteogenomic Profiling Reveals a Distinct Endogenous p16INK4a-Associated Senescence Signature in the Human OvaryDOI 10.64898/2026.02.02.703302
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