Article

Senescence-Linked Fibrosis in the Aging Human Ovary Revealed by p16-Based Histological Profiling and Spatial Transcriptomics

2026-02-06

Abstract excerpt

<title>Abstract</title> <p>Cellular senescence is implicated as a driver of ovarian aging, but senescent cells in the human postmenopausal ovary remain poorly defined. Using spatially resolved p16INK4a protein expression, a canonical senescence marker, we identified and mapped senescent cells in postmenopausal ovaries. We integrated p16 immunohistochemistry, multiplexed immunofluorescence, spatial transcriptomics...

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Literature Corpus work: c4cda964-0fc6-572d-a115-b74839d825ec
DOI: 10.21203/rs.3.rs-8290960/v1

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