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Article

A Hitchhiker's guide to humanized mice: new pathways to studying viral infections.

Immunology - 1 May 2018

Skelton Jessica Katy, Ortega-Prieto Ana Maria, Dorner Marcus

Abstract excerpt

Humanized mice are increasingly appreciated as an incredibly powerful platform for infectious disease research. The often very narrow species tropism of many viral infections, coupled with the sometimes misleading results from preclinical studies in animal models further emphasize the need for more predictive model systems based on human cells rather than surrogates. Humanized mice represent such a model and have...

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Identifiers

PMID: 29446074
DOI: 10.1111/imm.12906
PMCID: PMC5904706

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