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Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7

2020-04-25

Abstract excerpt

Humanized mouse models have become increasingly valuable tools to study human hematopoiesis and infectious diseases. However, human T cell differentiation remains inefficient. We generated mice expressing human interleukin (IL-7), a critical growth and survival factor for T cells, under the control of murine IL-7 regulatory elements. After transfer of human cord blood-derived hematopoietic stem and progenitor cell...

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Literature Corpus work
96b83162-d084-5b45-a111-77a87436d720
DOI
10.1101/2020.04.24.060319
Open publication

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Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7DOI 10.1101/2020.04.24.060319
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