Article

MutateX: an automated pipeline for <i>in-silico</i> saturation mutagenesis of protein structures and structural ensembles

2019-11-03

Abstract excerpt

Mutations resulting in amino acid substitution influence the stability of proteins along with their binding to other biomolecules. A molecular understanding of the effects induced by protein mutations are both of biotechnological and medical relevance. The availability of empirical free energy functions that quickly estimate the free energy change upon mutation (ΔΔG) can be exploited for systematic screenings of p...

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Literature Corpus work: 9f596488-ee28-541d-bcaa-76e82097d5c5
DOI: 10.1101/824938

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