Article

RosettaDDGPrediction for high-throughput mutational scans: from stability to binding

2022-09-04

Abstract excerpt

Reliable prediction of free energy changes upon amino acidic substitutions (ΔΔGs) is crucial to investigate their impact on protein stability and protein-protein interaction. Moreover, advances in experimental mutational scans allow high-throughput studies thanks to sophisticated multiplex techniques. On the other hand, genomics initiatives provide a large amount of data on disease-related variants that can benefi...

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Literature Corpus work: 3ddfce10-56ea-5741-9598-3260a7d1bb23
DOI: 10.1101/2022.09.02.506350

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