Article
Detection and sequence/structure mapping of biophysical constraints to protein variation in saturated mutational libraries and protein sequence alignments with a dedicated server.
BMC bioinformatics - 17 Jun 2016
Abriata Luciano A, Bovigny Christophe, Dal Peraro Matteo
Abstract excerpt
BACKGROUND: Protein variability can now be studied by measuring high-resolution tolerance-to-substitution maps and fitness landscapes in saturated mutational libraries. But these rich and expensive datasets are typically interpreted coarsely, restricting detailed analyses to positions of extremely high or low variability or dubbed important beforehand based on existing knowledge about active sites, interaction...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.