FoldX force field revisited, an improved version.

Abstract excerpt

MOTIVATION: The FoldX force field was originally validated with a database of 1000 mutants at a time when there were few high-resolution structures. Here, we have manually curated a database of 5556 mutants affecting protein stability, resulting in 2484 highly confident mutations denominated FoldX stability dataset (FSD), represented in non-redundant X-ray structures with <2.5 Å resolution, not involving...

Topics

• Databases, Protein
• Proteins
• Mutation
• Protein Stability
• Software
• Protein Folding
• Models, Molecular