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Article

RosettaDDGPrediction for high-throughput mutational scans: From stability to binding.

Protein science : a publication of the Protein Society - 1 Jan 2023

Sora Valentina, Laspiur Adrian Otamendi, Degn Kristine, Arnaudi Matteo, Utichi Mattia, Beltrame Ludovica, De Menezes Dayana, Orlandi Matteo, Stoltze Ulrik Kristoffer, Rigina Olga, Sackett Peter Wad, Wadt Karin, Schmiegelow Kjeld, Tiberti Matteo, Papaleo Elena

Abstract excerpt

Reliable prediction of free energy changes upon amino acid substitutions (ΔΔGs) is crucial to investigate their impact on protein stability and protein-protein interaction. Advances in experimental mutational scans allow high-throughput studies thanks to multiplex techniques. On the other hand, genomics initiatives provide a large amount of data on disease-related variants that can benefit from analyses with...

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PMID: 36461907
DOI: 10.1002/pro.4527
PMCID: PMC9795540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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