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Article

Dynamics intrinsic to cystic fibrosis transmembrane conductance regulator function and stability.

Cold Spring Harbor perspectives in medicine - 1 Mar 2013

Chong P Andrew, Kota Pradeep, Dokholyan Nikolay V, Forman-Kay Julie D

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) requires dynamic fluctuations between states in its gating cycle for proper channel function, including changes in the interactions between the nucleotide-binding domains (NBDs) and between the intracellular domain (ICD) coupling helices and NBDs. Such motions are also linked with fluctuating phosphorylation-dependent binding of CFTR's disordered...

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Source

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Identifiers

PMID: 23457292
DOI: 10.1101/cshperspect.a009522
PMCID: PMC3579207

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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