Article

Anti-tumor Effects of the eIF4A Inhibitor Didesmethylrocaglamide and Its Derivatives in Human and Canine Osteosarcomas

2024-06-14

Abstract excerpt

<title>Abstract</title> <p>Inhibition of translation initiation using eIF4A inhibitors like (-)-didesmethylrocaglamide [(-)-DDR] and (-)-rocaglamide [(-)-Roc] is a potential cancer treatment strategy as they simultaneously diminish multiple oncogenic drivers. We showed that human and dog osteosarcoma cells expressed high levels of eIF4A1/2, particularly eIF4A2. Genetic depletion of eIF4A1 and/or 2 slowed osteosar...

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Literature Corpus work: 9f3a012b-5656-52ef-ac0f-c28b501dfb15
DOI: 10.21203/rs.3.rs-4494024/v1

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